Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology
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چکیده
منابع مشابه
Biology of cardiac sodium channel Nav1.5 expression.
Na(v)1.5, the pore forming α-subunit of the voltage-dependent cardiac Na(+) channel, is an integral membrane protein involved in the initiation and conduction of action potentials. Mutations in the gene-encoding Na(v)1.5, SCN5A, have been associated with a variety of arrhythmic disorders, including long QT, Brugada, and sick sinus syndromes as well as progressive cardiac conduction defect and a...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2019
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.201800754